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Royal Caribbean: Greek Isles Cruise from Rome

Rome, Santorini, Ephesus, Mykonos, Naples
Ref: 7772394

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Tailor-make this holiday from £1,339pp

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Included in this Holiday

  • Direct international flights from London
  • 2-nights accommodation at the 4* Clarion Collection Hotel Principessa Isabella Rome
  • 7-night Greek Isles Cruise onboard Royal Caribbean Odyssey of the Seas
Price based on 2 people sharing. Price based on the 13th September 2026 sailing, but may be available on other sailing dates.
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Here’s What Your Amazing Holiday Could Look Like...

INCLUDES: Flights, accom & cruise.

Begin your journey with two unforgettable days exploring the Eternal City—Rome. Wander through ancient ruins, marvel at Renaissance masterpieces, and indulge in authentic Italian cuisine. Then, set sail on a luxurious cruise through the sun-drenched Greek Islands. Discover the whitewashed charm of Santorini, the vibrant culture of Mykonos, and the historic treasures of Ephesus, Turkey. A perfect blend of history, relaxation, and Mediterranean beauty.

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Planning your holiday

Hi I'm Chloe and as a Travel Consultant I'm here to make sure you find the exact holiday you want. This Journey itinerary is just one example for what's possible when you travel with us. Get in touch ...

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Your Example Itinerary

Day 1

Fly from the UK to Italy

Days 1-2

Rome, Italy

Spend two unforgettable days in the heart of Rome, where ancient history and modern life blend seamlessly. Stroll through the Colosseum and Roman Forum, toss a coin into the Trevi Fountain, and admire the grandeur of St. Peter’s Basilica. Savor authentic Italian cuisine in charming piazzas and explore hidden gems down cobbled alleyways. Whether it’s your first visit or a return to the Eternal City, Rome’s magic never fades.

Hotel: 4* Clarion Collection Hotel Principessa Isabella

Day 3

Rome, Italy (Embarkation)

Spend a final morning enjoying Rome before you board your ship this afternoon. The ship departs promptly at 4pm, so we advise to arrive 2-3 hours prior for check in, and to get settled into your cabin before departure.

Day 4

At Sea

While at sea, take time to recharge before the next adventure. Lounge by the pool, be spoiled at the spa, dine at any of the onboard restaurants or explore the thrills on each deck until we arrive at the next destination.

Day 5

Santorini, Greece

Santorini is one of the world’s most popular islands, where adventure bubbles above the Aegean Sea in breathtaking ways. Take a cable car to see Fira’s old cathedrals and enthralling museums. Swim in deep blue waters that lap black pebbled beaches. And peel back layers of history in excavated Akrotiri— all while relishing the dramatic scenery of this Cyclades isle.

Day 6

Ephesus (Kusadasi), Turkey

Head straight to the ancient city of Ephesus, a 20-minute drive from the port. Plan your visit based on how much you want to walk and how many sites you want to check out. The House of the Virgin Mary and the Basilica of St. John hold historical import as well as the traditional brick and stone architecture of the ancient near east. And of course, you can see the one remaining column of the Temple of Artemis, one of the Seven Wonders of the Ancient World.

Day 7

Mykonos, Greece

Powder white houses, sparkling blue waters, and red-hot nightlife— the Island of the Winds carries you away with colorful upscale adventures. Explore Hora’s bougainvillea-laced pathways and see the Folklore Museum’s Mykonian ship models. Join the raucous party on the shimmering sands of Super Paradise beach. Or watch the sunset from an open-air taverna— all nestled in the heart of Greece’s Cyclades islands.

Day 8

At Sea

With another day at sea, explore more of the facilities onboard Odyssey of the Seas. Whether you choose to cool down on the FlowRider, or enjoy one of the Outdoor Movie Nights, today is free to spend however you wish.

Day 9

Naples (Capri), Italy

The third-largest Italian city and one of the oldest in Europe, Naples combines deep history and modern verve. Check out the extravagant Royal Palace of Naples, the former home of the royal family, with its beautiful tapestries and frescoes. People-watch from a streetside cafe in the Sanita district with a glass of wine and slice of classic margherita pizza.

While in Naples, there are a range of shore excursions you can choose from - including visiting the ruins of Pompeii, seeing the stunning Amalfi Coast, or visiting the Isle of Capri.

Day 10

Rome, Italy

Today your cruise finishes back in Rome. Fly back to the UK later today, or if you wish to extend your stay in Italy, speak to your travel consultant who will be able to assist with car hire, accommodation and activities.

Day 10

Fly back to the UK from Italy

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Sun: 09:00 to 18:00

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